U.S. President Donald Trump says FDA Commissioner Dr. Marty Makary is leaving the post, ending a roughly 13-month tenure marked by repeated controversy and pressure from multiple sides. Several outlets report Makary’s resignation follows weeks of mounting complaints and institutional instability at the U.S. Department of Health and Human Services. Trump tells reporters Makary is not being fired, but leaving, and later posts an apparent message in which Makary offers his resignation. Trump thanks Makary for his work and says Kyle Diamantas, the FDA’s deputy commissioner for food, will lead the agency on an acting basis.

Across coverage, Makary is described as having upset figures in health care and industry as well as some Trump allies. Sources cited criticism from pharmaceutical executives, anti-abortion activists and vaping-related stakeholders. One flashpoint included the administration’s push to allow fruit-flavoured e-cigarettes despite Makary’s concerns about youth appeal. Other reported disputes involve drug and medical policy decisions and the FDA’s handling of health-related communications. Multiple reports describe broader plans for changes at the FDA and a “clean slate” approach within the Trump administration.