Alberta is seeing record numbers of opioid-related emergency medical services (EMS) calls in 2025, with health professionals and clinicians pointing to changes in the province’s toxic drug supply. Multiple reports say the increased call volume reflects more frequent overdose-related emergencies and greater challenges for responders as the potency and composition of available drugs shift. An addictions physician cited in the coverage notes he has observed changes in the drug supply in Edmonton and Calgary compared with what has been seen previously. The reports also describe growing concerns from patients themselves, who worry about the risk associated with the current supply. Together, the articles indicate that EMS and overdose-response efforts face added strain because existing response measures are being tested by variations in drug strength and effects. While the underlying causes of overdose incidents are complex, the shared focus across sources is that more potent or unpredictable drugs are contributing to a higher frequency of opioid-related emergencies and complicating how care is delivered in the field.