Study links photobiomodulation red-light therapy with potential benefits for brain injury

The Athletic reports that researchers at the University of Utah are studying itPBM, a medical-grade red-light therapy that has shown promising signs of reducing brain inflammation and improving cognition, mood, anxiety, motor performance and neural connectivity. The report centers in part on former BYU football star and University of Utah adjunct professor Larry Carr, who says the treatment helped him after years of brain damage from repeated head impacts. An anonymous reader shares an excerpt from the report: ... The knife, the call, the diagnosis in 2013, would lead [Carr] on a life-changing mission -- one in which he and a team of researchers at the University of Utah would eventually compile research that one of those researchers, Elisabeth Wilde, Ph.D, co-director of the Traumatic Brain Injury (TBI) and Concussion Center, calls "striking." The treatment they are studying is called photobiomodulation therapy, or itPBM (intranasal transcranial PBM), also known as red-light therapy. It is different from the kind of superficial red-light usage one can find on social media skincare channels or at a wellness boutique, and its application is broader. The research includes multiple studies, and is not just focused on ex-football players, but on women and men in various walks of life. The group recently published their latest results in the Journal of Neurotrauma, based on a study that followed 26 BYU football players throughout a season, suggesting the treatment could "potentially safeguard neurological health without reduced playing time or contact exposure." Definitive clinical trials haven't been run yet; broader research and validation is required, and some in the field are skeptical. Carr acknowledges some have told him that it could be "too good to be true." Still, other outside experts who spoke with The Athletic call the findings promising. They make sure to caution: This is not a cure-all, and there is much more to be tested. But the findings have been compelling enough to justify more research and more speculation. Researchers say 14 peer-reviewed studies have linked itPBM with improvements in cognition, mood, anxiety, attention, executive function, motor performance, and other measures, while brain imaging has shown reduced inflammation and improved connectivity. One of the most striking findings mentioned in the report came from a study of 26 BYU football players during the 2021 season. Players who did not receive treatment developed significant, widespread brain inflammation, while the treated group showed no comparable increase and even demonstrated reduced inflammation in some brain regions. As researcher Michael Carr put it, "I believe our BYU data suggests the players' brains using itPBM are actually healthier after the season." He added: "That is a first." Carr also said treated participants showed fewer symptoms of depression, anxiety, stress and PTSD, along with faster processing, better sustained attention and stronger executive function. Researchers have also observed improvements in balance, motor control and grip strength. Taken together, the findings suggest itPBM may have a neuroprotective effect. Read more of this story at Slashdot.

While more research is needed, a study following BYU football players gave experts reason for optimism.