A new systematic review suggests creatine monohydrate—a supplement commonly used in gyms—could potentially help as an add-on treatment for major depressive disorder. The studies reviewed indicate there may be a benefit when creatine is used alongside existing depression care, rather than as a standalone therapy. However, the review also emphasizes that the evidence is inconsistent across studies. Sources describe the findings as promising but not definitive, with researchers noting that more research is needed to confirm whether creatine reliably improves depressive symptoms and to clarify who may benefit most. While the supplement’s role remains uncertain, the review frames it as an adjunct option that would require further validation before any firm clinical recommendations. Both outlets report that researchers are careful about interpreting results, pointing to variability in study outcomes as a reason the supplement cannot yet be considered conclusive. The overall message is that creatine monohydrate may show potential in depression treatment, but further high-quality evidence is required.