OpenAI executive Fidji Simo, the company’s head of AGI deployment and its No. 2 figure, is stepping down from her full-time role following a prolonged medical leave. Multiple outlets report that Simo does not expect to return to her prior position after an illness-related leave that lasts longer than initially anticipated. Several reports describe the condition as chronic and say she is focusing on recovery.

Simo had taken medical leave in April, and in a public note she indicates that her treatment and recovery will require more time and involve greater complexity than expected. Sources also say OpenAI is preparing for a leadership transition as the company navigates operational and strategic milestones, including discussions around a possible initial public offering and efforts to expand enterprise deployments.

According to Bloomberg and other coverage, responsibilities tied to her role are being reassigned to other senior executives rather than left vacant. Several reports add that Simo will transition to an advisory capacity while stepping away from day-to-day duties.