The U.S. Food and Drug Administration has approved an over-the-counter fixed-dose combination of acetaminophen and naproxen sodium under the brand name Tylenol with Naproxen. According to FDA announcements covered by outlets, the product is positioned as opioid-free and is intended to provide extended pain relief from a single tablet. PR Newswire describes the approved fixed-dose combination as containing 650 mg of acetaminophen and 220 mg of naproxen sodium, and says it begins working in under 30 minutes and provides up to 12 hours of relief. MedPage Today reports an approval for a combination tablet containing 325 mg acetaminophen and 110 mg naproxen sodium for OTC pain relief. The reports characterize the approval as the first OTC fixed-dose combination of acetaminophen and naproxen sodium. Both sources frame the action as an FDA authorization that expands available OTC options for pain management, with the drug combination designed to be taken as a single dose for longer-lasting effects.